Development of a DNA aptamer targeting IDO1 with anti-tumor effects

Development of a DNA aptamer targeting IDO1 with anti-tumor effects

Blog Article

Summary: Immune checkpoint blockade has become an effective approach to reverse the immune tolerance of tumor cells.Indoleamine 2,3-dioxygenase 1 (IDO1) is frequently upregulated in many types of cancers and contributes to the establishment of an immunosuppressive cancer microenvironment, which has been thought to be a potential target for cancer therapy.However, the development bostik roll-cote of IDO1 inhibitors for clinical application is still limited.

Here, we isolated a DNA aptamer with a strong affinity and inhibitory activity against IDO1, designated as IDO-APT.By conjugating with nanoparticles, in situ injection of IDO-APT to CT26 tumor-bearing mice significantly suppresses the activity of regulatory T cells and promotes the function of CD8+ T cells, leading to tumor suppression and prolonged survival.Therefore, this functional IDO1-specific aptamer with potent anti-tumor effects may serve as a potential therapeutic strategy in cancer immunotherapy.

Our data u11-200ps provide an alternative way to target IDO1 in addition to small molecule inhibitors.